2023-05-082023-05-082023-05-082022-01-11http://repositorio.ifam.edu.br/jspui/handle/4321/1190Canine atopic dermatitis (CAD) is characterized as a chronic, inflammatory and pruritic multifactorial disease, which mainly affects breeds such as Golden Retrievers, Labradors and Terriers between 1 and 3 years. It is a genetic disease influenced by immune dysregulation and environmental factors such as allergen exposure. Itching is the main symptom, with type I hypersensitivity being responsible for triggering the disease. In addition to the failure of the skin barrier, CAD is due to an exacerbated immune response mediated by IgE after a second contact with the causative agent, releasing inflammatory mediators and self-perpetuating the pruritus cycle. Animals with CAD respond well to glucocorticoids, but due to their side effects, other safer alternatives, such as immunomodulators, have been constantly being developed. The objective of this work is to describe the mechanisms involved in the inflammatory response of dogs with CAD. Key-words: Type I hipersensitivity. Skin barrier. Imunopathogenesis.Acesso AbertoHipersensibilidade do tipo I. Barreira cutânea. Imunopatogenia.CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIATrabalho de Conclusão de Curso